On 7th July, KTN held a webinar on viral vector analysis. This event discussed the current state of the art, challenges and potential solutions around analysis of adeno-associated virus and lentiviral vectors.

Webinar recording is now available

Watch this recording to hear about the current state of the art for viral vector analytics, as well as its challenges. In addition, we covered potential solutions.

 

The event included contributions from speakers representing companies, academia, RTOs and others. In addition, there was an opportunity for solution providers to provide a short two minute video to be shared with attendees in a video gallery. Two of the submissions were selected by the organising committee for plenary display. The final session was a panel discussion to revisit the issues raised in the preceding presentations.

Confirmed speakers and panelists

●  Farzin Farzaneh, Chief Scientific Officer, ViroCell Biologics
●  Julia Leach, Senior Scientist – Analytical, CPI
●  Peng Wang, Scientist II, Lonza
●  Yuan Zhao, Principal Scientist / Section Head, NIBSC
●  Mike Baker, Senior Director, FUJIFILM Diosynth Biotechnologies
●  Alan Dickson, Professor of Biotechnology, University of Manchester

Organising committee

●  Karen Wilkinson, KTN
●  Marcel Kuiper, KTN
●  Joanne Flannelly, University of Manchester / BioProNET2
●  Alan Dickson, University of Manchester / BioProNET2
●  Rebecca Horlock, FUJIFILM Diosynth Biotechnologies
●  Daniel Petit, FUJIFILM Diosynth Biotechnologies
●  Robert Forbes, University of Central Lancashire / FUJIFILM Diosynth
Biotechnologies
●  Julia Leach, CPI
●  Lee Dunham, Cell and Gene Therapy Catapult

Draft Agenda

  • 14:00 – Welcome and KTN update | Karen Wilkinson  KTN

Session 1: Challenges for viral vector analytics. Chair: Mike Baker (FUJIFILM Diosynth Biotechnologies)

14:10 – 14:25 “Lentiviral vectors: exciting developments, challenges and new opportunities”  Farzin Farzaneh  Chief Scientific Officer, ViroCell, Professor of Molecular Medicine, King’s College London

14:25 – 14:40  “AAV viral vector analysis; state of the art and challenges”  Peng Wang  Scientist II, Lonza

14:40 – 15:55  “Regulatory considerations for AAV and lentiviral vector analytics”  Yuan Zhao, Principal Scientist, NIBSC

14:55 – 15:05  Q&A

Session 2: Exploration of novel tools and solutions. Chair: Julia Leach, CPI

15:05 – 15:20 “A Top-Down Approach to Gene Therapy Product Characterisation: addressing Critical Quality Attributes from intact capsids to amino acid modifications”, Ian Anderson, Associate Director, Analytical Sciences, Pharmaron

15:20 – 15:25 Two selected videos from analytics solution providers

15:25 – 15:40 “Future direction analytical capabilities”, Lily Li, Cell and Gene Therapy Catapult

15:40 – 15:50  Q&A

15:50 – 16:00  Break, novel solution videos

Session 3: Round table discussion led by Prof Alan Dickson (University of Manchester)

Participation from Farzin Farzaneh (ViroCell/King’s College London), Yuan Zhao (NIBSC), Julia Leach (CPI), Mike Baker (FUJIFILM Diosynth Biotechnologies), Lily Li (Cell and Gene Therapy Catapult), Peng Wang (Lonza), Ian Anderson (Pharmaron), Jonathan Appleby (Cell and Gene Therapy Catapult) and Nick Pittman (Waters).

16:00 – 16:45

●  Key challenges

●  Learnings from other biopharmaceuticals

●  Novel technologies

●  Future regulatory expectations

●  Next steps

16:45 – 17:30  1:1 video networking, novel solution videos